Article
'Evaluation of adverse prognostic gene alterations & MRD positivity in BCR::ABL1-like B-lineage acute lymphoblastic leukaemia patients, in a resource-constrained setting.
British journal of cancer - 1 Jul 2023
Gupta Dikshat Gopal, Varma Neelam, Sreedharanunni Sreejesh, Abdulkadir Sarki Abba, Naseem Shano, Sachdeva Man Updesh Singh, Binota Jogeshwar, Bose Parveen, Malhotra Pankaj, Khadwal Alka, Varma Subhash
Abstract excerpt
BACKGROUND: Early detection of BCR::ABL1-like ALL could impact treatment management and improve the overall survival/outcome. BCR::ABL1-like ALL cases are characterised by diverse genetic alterations activating cytokine receptors and kinase signalling. Its detection is still an unmet need in low-middle-income countries due to the unavailability of a patented TLDA assay. METHODS: This study's rationale is to...
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