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Article

Distinct but interchangeable subpopulations of colorectal cancer cells with different growth fates and drug sensitivity

13 Jan 2023

Abstract excerpt

Dynamic changes in cell properties lead to intratumor heterogeneity; however, the mechanisms of nongenetic cellular plasticity remain elusive. When the fate of each cell from colorectal cancer organoids was tracked through a clonogenic growth assay, the cells showed a wide range of growth ability even within the clonal organoids, consisting of distinct subpopulations; the cells generating large spheroids and the...

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PMID: 36718360
DOI: 10.1016/j.isci.2023.105962

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