Article
Role of paraoxonase 1 activity and PON1 gene polymorphisms in sickle cell disease.
Scientific reports - 3 May 2023
Menezes Joelma Figueiredo, Carvalho Magda Oliveira Seixas, Rocha Larissa Carneiro, Dos Santos Felipe Miranda, Adorno Elisângela Vitória, de Souza Cyntia Cajado, Santiago Rayra Pereira, da Guarda Caroline Conceição, de Oliveira Rodrigo Mota, Figueiredo Camylla Vilas Boas, Carvalho Suéllen Pinheiro, Yahouédéhou Sètondji Cocou Modeste Alexandre, Fiuza Luciana Magalhães, Adanho Corynne Stéphanie Ahouefa, Pitanga Thassila Nogueira, Lyra Isa Menezes, Nascimento Valma Maria Lopes, Noronha-Dutra Alberto Augusto, Goncalves Marilda Souza
Abstract excerpt
Sickle cell disease (SCD) patients often exhibit a dyslipidemic sub-phenotype. Paraoxonase 1 (PON 1) is a serum glycoprotein associated with the high-density lipoproteins cholesterol (HDL-C), and variability in PON1 activity depends on the PON1 genotypes. We investigated the influence of PON1c.192Q > R and PON1c.55L > M polymorphisms on PON1 activity and laboratory parameters and the association between PON1...
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