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Article

The substrate selectivity of papain-like proteases from human-infecting coronaviruses correlates with innate immune suppression

2 May 2023

Abstract excerpt

Coronaviruses that can infect humans can cause either common colds (HCoV-NL63, HCoV-229E, HCoV-HKU1, and HCoV-OC43) or severe respiratory symptoms (SARS-CoV-2, SARS-CoV, and MERS-CoV). The papain-like proteases (PLPs) of SARS-CoV, SARS-CoV-2, MERS-CoV, and HCoV-NL63 function in viral innate immune evasion and have deubiquitinating (DUB) and deISGylating activities. We identified the PLPs of HCoV-229E, HCoV-HKU1,...

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Identifiers

PMID: 37130166
DOI: 10.1126/scisignal.ade1985

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