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Article

Structural basis for catalysis and ubiquitin recognition by the severe acute respiratory syndrome coronavirus papain-like protease.

Acta crystallographica. Section D, Biological crystallography - 1 Feb 2014

Chou Chi-Yuan, Lai Hsing-Yi, Chen Hung-Yi, Cheng Shu-Chun, Cheng Kai-Wen, Chou Ya-Wen

Abstract excerpt

Papain-like protease (PLpro) is one of two cysteine proteases involved in the proteolytic processing of the polyproteins of Severe acute respiratory syndrome coronavirus (SARS-CoV). PLpro also shows significant in vitro deubiquitinating and de-ISGylating activities, although the detailed mechanism is still unclear. Here, the crystal structure of SARS-CoV PLpro C112S mutant in complex with ubiquitin (Ub) is...

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Identifiers

PMID: 24531491
DOI: 10.1107/S1399004713031040
PMCID: PMC7161584

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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