Article
RAS-Driven Macropinocytosis of Albumin or Dextran Reveals Mutation-Specific Target Engagement of RAS p.G12C Inhibitor ARS-1620 by NIR-Fluorescence Imaging.
Molecular imaging and biology - 1 Jun 2022
Sutton Margie N, Gammon Seth T, Muzzioli Riccardo, Pisaneschi Federica, Radaram Bhasker, Yang Ping, Piwnica-Worms David
Abstract excerpt
PURPOSE: Macropinocytosis serves as a highly conserved endocytotic process that has recently been shown as a critical mechanism by which RAS-transformed cells transport extracellular protein into intracellular amino acid pathways to support their unique metabolic needs. We developed NIR fluorescently labeled molecular imaging probes to monitor macropinocytosis-mediated uptake of albumin in a K-RAS-dependent...
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