Article

Exercise induces Skeletal Muscle Methylome and Transcriptome changes, regardless of Age and COPD

2026-03-09

Abstract excerpt

Skeletal muscle atrophy and deconditioning contribute to functional limitation and disability in COPD. While transcriptome and DNA methylation changes accompany exercise in healthy muscle, their interaction with COPD status and ageing, and integrative analyses of methylome–transcriptome responses have not been explored. We performed gene expression and DNA methylation profiling in skeletal muscle of sedentary volu...

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Literature Corpus work: e591def1-e5ef-5bd1-8e6d-9f94e61da7b3
DOI: 10.64898/2026.03.06.710054

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