Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Myocardial Notch signaling reprograms cardiomyocytes to a conduction-like phenotype.

Circulation - 28 Aug 2012

Rentschler Stacey, Yen Alberta H, Lu Jia, Petrenko Nataliya B, Lu Min Min, Manderfield Lauren J, Patel Vickas V, Fishman Glenn I, Epstein Jonathan A

Abstract excerpt

BACKGROUND: Notch signaling has previously been shown to play an essential role in regulating cell fate decisions and differentiation during cardiogenesis in many systems including Drosophila, Xenopus, and mammals. We hypothesized that Notch may also be involved in directing the progressive lineage restriction of cardiomyocytes into specialized conduction cells. METHODS AND RESULTS: In hearts where Notch...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Action Potentials
Share to Adenoviridae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homeobox Protein Nkx-2.5

Share to NAV1.5 Voltage-Gated Sodium Channel

Share to Neuronal Plasticity

Share to Receptor, Notch1

Share to T-Box Domain Proteins

Share to Transcription Factor HES-1

Source

Open in PubMed Open full text

Identifiers

PMID: 22837163
DOI: 10.1161/CIRCULATIONAHA.112.103390
PMCID: PMC3607542

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Myocardial Notch signaling reprograms cardiomyocytes to a conduction-like phenotype.PMID 22837163Read ↗

Role of Notch signaling in the mammalian heartSemantic proximity Read ↗

Impaired Human Cardiac Cell Development due to NOTCH1 DeficiencySemantic proximity Read ↗

Gene regulatory networks in cardiac conduction system development.Semantic proximity Read ↗

Transient Notch Activation Converts Pluripotent Stem Cell-Derived Cardiomyocytes Towards a Purkinje Fiber FateSemantic proximity Read ↗

Activation of Notch signaling in cardiomyocytes during post-infarction remodelingSemantic proximity Read ↗

FGF signaling enforces cardiac chamber identity in the developing ventricleSemantic proximity Read ↗

Conducting the embryonic heart: orchestrating development of specialized cardiac tissues.Semantic proximity Read ↗

Notch and interacting signalling pathways in cardiac development, disease, and regenerationSemantic proximity Read ↗

Specification of the cardiac conduction system by transcription factors.Semantic proximity Read ↗

The cardiac pacemaker and conduction system develops from embryonic myocardium that retains its primitive phenotype.Semantic proximity Read ↗

Establishment of the mouse ventricular conduction system.Semantic proximity Read ↗

Notch signalling in ventricular chamber development and cardiomyopathySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.