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Generation of a human induced pluripotent stem cell (iPSC, DVSi001-A) with a heterozygous mutation in KRAS (A209T).

Stem cell research - 1 Oct 2024

Wang Xu, Zhuang Hao, Tan Yuting, Lei Fengrui, Li Chenglong, Zhang Chuang, Yu Xiaobin, Sang Hongfei

Abstract excerpt

Human varicose veins are commonly claimed to be responsible for lower limb symptoms. Mutation in KRAS gene has been implicated in various diseases, including cancers and vascular diseases. While little known about the novel mutation in KRAS gene and its contribution to the development of varicose veins. Here, we have generated human induced pluripotent stem cell (iPSC) line, which harboured a novel mutation in...

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PMID: 39106598
DOI: 10.1016/j.scr.2024.103528

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