Article
High-grade serous ovarian carcinoma and detection of inactivated BRCA genes from biopsy material of Slovak patients.
Neoplasma - 1 Sept 2021
Janíková Katarína, Váňová Barbora, Grendár Marián, Samec Marek, Líšková Alenka, Loderer Dušan, Kašubová Ivana, Farkašová Anna, Scheerova Karla, Slávik Pavol, Lasabová Zora, Danková Zuzana, Plank Lukáš
Abstract excerpt
Ovarian cancer is the leading cause of mortality among all gynecological cancers in developed countries and its most common and most lethal type is the high-grade serous ovarian carcinoma (HGSC). At the molecular level, nearly half of all HGSCs exhibit ineffective homologous DNA recombination and disruption of DNA damage/repair pathway inactivation caused often by BRCA1 and BRCA2 gene mutation. Recently, the...
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