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Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial

9 Feb 2023

Abstract excerpt

Abstract The geroscience hypothesis proposes that therapy to slow or reverse molecular changes that occur with aging can delay or prevent multiple chronic diseases and extend healthy lifespan 1–3 . Caloric restriction (CR), defined as lessening caloric intake without depriving essential nutrients 4 , results in changes in molecular processes that have been associated with aging, including DNA methylation (DNAm)...

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PMID: 37118425
DOI: 10.1038/s43587-022-00357-y

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