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Effect of long‐term caloric restriction on telomere length in healthy adults: CALERIE™ 2 trial analysis

19 Mar 2024

Abstract excerpt

Abstract Caloric restriction (CR) modifies lifespan and aging biology in animal models. The Comprehensive Assessment of Long‐Term Effects of Reducing Intake of Energy (CALERIE™) 2 trial tested translation of these findings to humans. CALERIE™ randomized healthy, nonobese men and premenopausal women (age 21–50y; BMI 22.0–27.9 kg/m2), to 25% CR or ad‐libitum (AL) control (2:1) for 2 years. Prior analyses of...

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PMID: 38504468
DOI: 10.1111/acel.14149

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