Article

Development of Cell-based High Throughput Luminescence Assay for Drug Discovery in Inhibiting OCT4 and MAPKAPK2 Interaction

2020-10-21

Abstract excerpt

Overexpression of c-MYC protein without genomic amplification occurs in multiple cancers, including neuroblastoma and small cell lung cancer. In searching for the mechanisms of c-MYC protein overexpression, we demonstrated that the transcription factor, OCT4 mediates c-MYC transcriptional activation in progressive disease neuroblastoma. Subsequently, we identified two kinases, MAPKAPK2 (MK2) and DNA-PK, which are...

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Literature Corpus work: ea75b9be-58c9-5ba1-8728-2d2d1ac5769e
DOI: 10.22541/au.160331923.36989531/v1

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