Article
Targeted genetic dependency screen facilitates identification of actionable mutations in FGFR4, MAP3K9, and PAK5 in lung cancer.
Proceedings of the National Academy of Sciences of the United States of America - 23 Jul 2013
Fawdar Shameem, Trotter Eleanor W, Li Yaoyong, Stephenson Natalie L, Hanke Franziska, Marusiak Anna A, Edwards Zoe C, Ientile Sara, Waszkowycz Bohdan, Miller Crispin J, Brognard John
Abstract excerpt
Approximately 70% of patients with non-small-cell lung cancer present with late-stage disease and have limited treatment options, so there is a pressing need to develop efficacious targeted therapies for these patients. This remains a major challenge as the underlying genetic causes of ~50% of non-small-cell lung cancers remain unknown. Here we demonstrate that a targeted genetic dependency screen is an efficient...
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