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Article

Evolution of Resistance to Irinotecan in Cancer Cells Involves Generation of Topoisomerase-Guided Mutations in Non-Coding Genome That Reduce the Chances of DNA Breaks.

International journal of molecular sciences - 13 May 2023

Kumar Santosh, Gahramanov Valid, Patel Shivani, Yaglom Julia, Kaczmarczyk Lukasz, Alexandrov Ivan A, Gerlitz Gabi, Salmon-Divon Mali, Sherman Michael Y

Abstract excerpt

Resistance to chemotherapy is a leading cause of treatment failure. Drug resistance mechanisms involve mutations in specific proteins or changes in their expression levels. It is commonly understood that resistance mutations happen randomly prior to treatment and are selected during the treatment. However, the selection of drug-resistant mutants in culture could be achieved by multiple drug exposures of cloned...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37240063
DOI: 10.3390/ijms24108717
PMCID: PMC10218574

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