Development of sensitive and robust multiplex digital PCR assays for the detection of ESR1 mutations in the plasma of metastatic breast cancer patients.

doi:10.1016/j.cca.2023.117366

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Development of sensitive and robust multiplex digital PCR assays for the detection of ESR1 mutations in the plasma of metastatic breast cancer patients.

Clinica chimica acta; international journal of clinical chemistry - 1 May 2023

Corné Julien, Quillien Véronique, Callens Céline, Portois Pascal, Bidard François-Clément, Jeannot Emmanuelle, Godey Florence, Le Du Fanny, Robert Lucie, Bourien Héloïse, Brunot Angélique, Crouzet Laurence, Perrin Christophe, Lefeuvre-Plesse Claudia, Diéras Véronique, de la Motte Rouge Thibault

Abstract excerpt

BACKGROUND: Early detection of ESR1 mutations is a key element for better personalization of the management of patients with HR+/HER2- Metastatic Breast Cancer (MBC). Analysis of circulating tumor DNA from liquid biopsies is a particularly well-suited strategy for longitudinal monitoring of such patients. MATERIALS AND METHODS: Using the naica® three-color digital PCR platform, we developed a screening assay...

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PMID: 37105452
DOI: 10.1016/j.cca.2023.117366

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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