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Plasma-based analysis of ERBB2 mutational status by multiplex digital PCR in a large series of patients with metastatic breast cancer.

Molecular oncology - 1 Nov 2024

Corné Julien, Quillien Véronique, Godey Florence, Cherel Mathilde, Cochet Agathe, Le Du Fanny, Robert Lucie, Bourien Héloïse, Brunot Angélique, Crouzet Laurence, Perrin Christophe, Lefeuvre-Plesse Claudia, Diéras Véronique, De la Motte Rouge Thibault

Abstract excerpt

Erb-b2 receptor tyrosine kinase 2 (ERBB2)-activating mutations are therapeutically actionable alterations found in various cancers, including metastatic breast cancer (MBC). We developed multiplex digital PCR assays to detect and quantify ERBB2 mutations in circulating tumor DNA from liquid biopsies. We studied the plasma from 272 patients with hormone-receptor-positive, human epidermal growth factor receptor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38287892
DOI: 10.1002/1878-0261.13592
PMCID: PMC11547241

Genes

ERBB2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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