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Article

Alphavirus infection triggers antiviral RNAi immunity in mammals

26 Apr 2023

Abstract excerpt

RNA interference (RNAi) is a well-established antiviral immunity. However, for mammalian somatic cells, antiviral RNAi becomes evident only when viral suppressors of RNAi (VSRs) are disabled by mutations or VSR-targeting drugs, thereby limiting its scope as a mammalian immunity. We find that a wild-type alphavirus, Semliki Forest virus (SFV), triggers the Dicer-dependent production of virus-derived small...

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PMID: 37104090
DOI: 10.1016/j.celrep.2023.112441

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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