Human Virus-Derived Small RNAs Can Confer Antiviral Immunity in Mammals.

doi:10.1016/j.immuni.2017.05.006

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Article

Human Virus-Derived Small RNAs Can Confer Antiviral Immunity in Mammals.

Immunity - 20 Jun 2017

Qiu Yang, Xu Yanpeng, Zhang Yao, Zhou Hui, Deng Yong-Qiang, Li Xiao-Feng, Miao Meng, Zhang Qiang, Zhong Bo, Hu Yuanyang, Zhang Fu-Chun, Wu Ligang, Qin Cheng-Feng, Zhou Xi

Abstract excerpt

RNA interference (RNAi) functions as a potent antiviral immunity in plants and invertebrates; however, whether RNAi plays antiviral roles in mammals remains unclear. Here, using human enterovirus 71 (HEV71) as a model, we showed HEV71 3A protein as an authentic viral suppressor of RNAi during viral infection. When the 3A-mediated RNAi suppression was impaired, the mutant HEV71 readily triggered the production of...

Topics

Animals
Argonaute Proteins
Clustered Regularly Interspaced Short Palindromic Repeats
Enterovirus A, Human
Enterovirus Infections
HEK293 Cells
Humans
Immunity
Mammals
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, 129 Strain

Mice, Knockout

Mutation

RNA Interference

RNA, Viral

Ribonuclease III

Viral Proteins

Source

Open in PubMed

Identifiers

PMID: 28636969
DOI: 10.1016/j.immuni.2017.05.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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