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TP53 somatic mutations in Asian breast cancer are associated with subtype-specific effects.

Breast cancer research : BCR - 26 Apr 2023

Ragu Mohana Eswari, Lim Joanna Mei Ch'wan, Ng Pei-Sze, Yip Cheng-Har, Rajadurai Pathmanathan, Teo Soo-Hwang, Pan Jia-Wern

Abstract excerpt

BACKGROUND: Recent genomics studies of breast cancer in Asian cohorts have found a higher prevalence of TP53 mutations in Asian breast cancer patients relative to Caucasian patients. However, the effect of TP53 mutations on Asian breast tumours has not been comprehensively studied. METHODS: Here, we report an analysis of 492 breast cancer samples from the Malaysian Breast Cancer cohort where we examined the...

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Identifiers

PMID: 37101199
DOI: 10.1186/s13058-023-01635-2
PMCID: PMC10134541

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