Article
Combining the amplification refractory mutation system and high-resolution melting analysis for KRAS mutation detection in clinical samples.
Analytical and bioanalytical chemistry - 1 Jun 2023
Oliveira Beatriz B, Costa Beatriz, Morão Barbara, Faias Sandra, Veigas Bruno, Pereira Lucília Pebre, Albuquerque Cristina, Maio Rui, Cravo Marília, Fernandes Alexandra R, Baptista Pedro Viana
Abstract excerpt
The success of personalized medicine depends on the discovery of biomarkers that allow oncologists to identify patients that will benefit from a particular targeted drug. Molecular tests are mostly performed using tumor samples, which may not be representative of the tumor's temporal and spatial heterogeneity. Liquid biopsies, and particularly the analysis of circulating tumor DNA, are emerging as an interesting...
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