Transforming RNA-Seq gene expression to track cancer progression in the multi-stage early to advanced-stage cancer development

Abstract excerpt

BACKGROUND: Cancer progression can be tracked by gene expression changes that occur throughout early-stage to advanced-stage cancer development. The accumulated genetic changes can be detected when gene expression levels in advanced-stage are less variable but show high variability in early-stage. Normalizing advanced-stage expression samples with early-stage and clustering of the normalized expression samples...

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