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Integrative proteomics in prostate cancer uncovers robustness against genomic and transcriptomic aberrations during disease progression

21 Mar 2018

Abstract excerpt

To understand functional consequences of genetic and transcriptional aberrations in prostate cancer, the proteomic changes during disease formation and progression need to be revealed. Here we report high-throughput mass spectrometry on clinical tissue samples of benign prostatic hyperplasia (BPH), untreated primary prostate cancer (PC) and castration resistant prostate cancer (CRPC). Each sample group shows a...

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PMID: 29563510
DOI: 10.1038/s41467-018-03573-6

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