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Article

Hypoxia regulates fibrosis-related genes via histone lactylation in the placentas of patients with preeclampsia

1 Jun 2022

Abstract excerpt

BACKGROUND: Histone lactylation, a novel epigenetic modification induced by hypoxia and lactate, plays an important role in regulating gene expression. However, the role of histone lactylation in the pathogenesis of preeclampsia remains unknown. METHODS: Placentas from preeclamptic patients and control pregnant women were collected for protein immunoassay to detect the expression level of histone lactylation, and...

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PMID: 35703881
DOI: 10.1097/hjh.0000000000003129

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