UBTF tandem duplications are rare but recurrent alterations in adult AML and associated with younger age, myelodysplasia, and inferior outcome.

doi:10.1038/s41408-023-00858-y

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UBTF tandem duplications are rare but recurrent alterations in adult AML and associated with younger age, myelodysplasia, and inferior outcome.

Blood cancer journal - 26 May 2023

Georgi Julia-Annabell, Stasik Sebastian, Eckardt Jan-Niklas, Zukunft Sven, Hartwig Marita, Röllig Christoph, Middeke Jan Moritz, Oelschlägel Uta, Krug Utz, Sauer Tim, Scholl Sebastian, Hochhaus Andreas, Brümmendorf Tim H, Naumann Ralph, Steffen Björn, Einsele Hermann, Schaich Markus, Burchert Andreas, Neubauer Andreas, Schäfer-Eckart Kerstin, Schliemann Christoph, Krause Stefan W, Hänel Mathias, Noppeney Richard, Kaiser Ulrich, Baldus Claudia D, Kaufmann Martin, Müller-Tidow Carsten, Platzbecker Uwe, Berdel Wolfgang E, Serve Hubert, Ehninger Gerhard, Bornhäuser Martin, Schetelig Johannes, Kroschinsky Frank, Thiede Christian

Abstract excerpt

Tandem-duplication mutations of the UBTF gene (UBTF-TDs) coding for the upstream binding transcription factor have recently been described in pediatric patients with acute myeloid leukemia (AML) and were found to be associated with particular genetics (trisomy 8 (+8), FLT3-internal tandem duplications (FLT3-ITD), WT1-mutations) and inferior outcome. Due to limited knowledge on UBTF-TDs in adult AML, we screened...

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PMID: 37236968
DOI: 10.1038/s41408-023-00858-y
PMCID: PMC10220021

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