Article

<i>UBTF</i>Tandem Duplications in Pediatric MDS and AML: Implications for Clinical Screening and Diagnosis

2023-11-13

Abstract excerpt

Recent genomic studies in adult and pediatric acute myeloid leukemia (AML) demonstrated recurrent in-frame tandem duplications (TD) in exon 13 of upstream binding transcription factor ( UBTF ). These alterations, which account for ~4.3% of AMLs in childhood and up to 3% in adult AMLs under 60, are subtype-defining and associated with poor outcomes. Here, we provide a comprehensive investigation into the clinicopat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: aa1eea6e-e582-58e6-a90b-305843c9427c
DOI: 10.1101/2023.11.13.23298320

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>UBTF</i>Tandem Duplications in Pediatric MDS and AML: Implications for Clinical Screening and DiagnosisDOI 10.1101/2023.11.13.23298320Read

UBTF tandem duplications in pediatric myelodysplastic syndrome and acute myeloid leukemia: implications for clinical screening and diagnosis.Semantic proximity Read

Integrated Genomic Analysis Identifies <i>UBTF</i> Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid LeukemiaSemantic proximity Read

UBTF tandem duplications are rare but recurrent alterations in adult AML and associated with younger age, myelodysplasia, and inferior outcome.Semantic proximity Read

UBTF tandem duplications define a distinct subtype of adult de novo acute myeloid leukemia.Semantic proximity Read

UBTF-internal tandem duplication as a novel poor prognostic factor in pediatric acute myeloid leukemia.Semantic proximity Read

Germline and somatic genetic landscape of pediatric myelodysplastic syndromesSemantic proximity Read

Analysis of rare driving events in pediatric acute myeloid leukemia.Semantic proximity Read

Acute myeloid leukemias with <i>UBTF</i> tandem duplications are sensitive to menin inhibitorsSemantic proximity Read

Cellular and molecular architecture of hematopoietic stem cells and progenitors in genetic models of bone marrow failure.Semantic proximity Read

RUNX1 Alterations in Pediatric Myeloid Malignancies: Divergent Germline and Somatic Trajectories.Semantic proximity Read

Transcriptome analysis offers a comprehensive illustration of the genetic background of pediatric acute myeloid leukemia.Semantic proximity Read

Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse.Semantic proximity Read