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Article

Common genetic variations in telomere length genes and lung cancer: a Mendelian randomisation study and its novel application in lung tumour transcriptome.

eLife - 20 Apr 2023

Cortez Cardoso Penha Ricardo, Smith-Byrne Karl, Atkins Joshua R, Haycock Philip C, Kar Siddhartha, Codd Veryan, Samani Nilesh J, Nelson Christopher, Milojevic Maja, Gabriel Aurélie A G, Amos Christopher, Brennan Paul, Hung Rayjean J, Kachuri Linda, Mckay James D

Abstract excerpt

Background: Genome-wide association studies (GWASs) have identified genetic susceptibility variants for both leukocyte telomere length (LTL) and lung cancer susceptibility. Our study aims to explore the shared genetic basis between these traits and investigate their impact on somatic environment of lung tumours. Methods: We performed genetic correlation, Mendelian randomisation (MR), and colocalisation analyses...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37079368
DOI: 10.7554/eLife.83118
PMCID: PMC10118386

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