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Genome-wide CRISPR screening identifies LRP1 as an entry factor for SFTSV

29 Apr 2025

Abstract excerpt

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease caused by the SFTS virus (SFTSV), which has high mortality rates and poses a significant threat to public health. To identify potential therapeutic targets against SFTSV, we conduct genome-wide knockout screening, which identifies the previously known host factor CCR2, and reveals prolow-density lipoprotein receptor-related...

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PMID: 40301361
DOI: 10.1038/s41467-025-59305-0

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