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Uncovering Flavivirus Host Dependency Factors through a Genome-Wide Gain-of-Function Screen

15 Jan 2019

Abstract excerpt

Flaviviruses, such as dengue (DENV), West Nile (WNV), yellow fever (YFV) and Zika (ZIKV) viruses, are mosquito-borne pathogens that present a major risk to global public health. To identify host factors that promote flavivirus replication, we performed a genome-wide gain-of-function cDNA screen for human genes that enhance the replication of flavivirus reporter particles in human cells. The screen recovered...

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PMID: 30650657
DOI: 10.3390/v11010068

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