Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Oropouche orthobunyavirus infection is mediated by the cellular host factor Lrp1

8 Aug 2022

Abstract excerpt

) is a mosquito-transmitted virus that causes widespread human febrile illness in South America, with occasional progression to neurologic effects. Host factors mediating the cellular entry of OROV are undefined. Here, we show that OROV uses the host protein low-density lipoprotein-related protein 1 (Lrp1) for efficient cellular infection. Cells from evolutionarily distinct species lacking Lrp1 were less...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mosquito-borne diseases and control
Share to Vector-Borne Animal Diseases
Share to Viral Infections and Vectors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35939689
DOI: 10.1073/pnas.2204706119

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Oropouche orthobunyavirus infection is mediated by the cellular host factor Lrp1PMID 35939689Read ↗

Low-density lipoprotein receptor–related protein 1 (LRP1) as an auxiliary host factor for RNA virusesSemantic proximity Read ↗

Oropouche Virus Infection and Pathogenesis Are Restricted by MAVS, IRF-3, IRF-7, and Type I Interferon Signaling Pathways in Nonmyeloid CellsSemantic proximity Read ↗

Identification of Novel Host Cell Binding Partners of Oas1b, the Protein Conferring Resistance to Flavivirus-Induced Disease in MiceSemantic proximity Read ↗

The VLDLR entry receptor is required for the pathogenesis of multiple encephalitic alphavirusesSemantic proximity Read ↗

An Innate Immunity-Regulating Virulence Determinant Is Uniquely Encoded within the Andes Virus Nucleocapsid ProteinSemantic proximity Read ↗

Integrated <i>in vivo</i> and transcriptomic analyses of lethal Oropouche virus infection reveal suppression of pathogenic host responses by antiviral therapySemantic proximity Read ↗

Structural determinants of chemokine binding by an Ectromelia virus-encoded decoy receptor.Semantic proximity Read ↗

Differential tropisms of old and new world hantaviruses influence virulence and developing host-directed antiviral candidatesSemantic proximity Read ↗

Endocytic Pathways Used by Andes Virus to Enter Primary Human Lung Endothelial CellsSemantic proximity Read ↗

The low-density lipoprotein receptor promotes infection of multiple encephalitic alphavirusesSemantic proximity Read ↗

LDLR is used as a cell entry receptor by multiple alphavirusesSemantic proximity Read ↗

A STAT-1 knockout mouse model for Machupo virus pathogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.