Article
The association of genome-wide significant spirometric loci with chronic obstructive pulmonary disease susceptibility.
American journal of respiratory cell and molecular biology - 1 Dec 2011
Castaldi Peter J, Cho Michael H, Litonjua Augusto A, Bakke Per, Gulsvik Amund, Lomas David A, Anderson Wayne, Beaty Terri H, Hokanson John E, Crapo James D, Laird Nan, Silverman Edwin K
Abstract excerpt
Two recent metaanalyses of genome-wide association studies conducted by the CHARGE and SpiroMeta consortia identified novel loci yielding evidence of association at or near genome-wide significance (GWS) with FEV(1) and FEV(1)/FVC. We hypothesized that a subset of these markers would also be associated with chronic obstructive pulmonary disease (COPD) susceptibility. Thirty-two single-nucleotide polymorphisms...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.