Article
Breast cancer polygenic risk scores derived in White European populations are not calibrated for women of Ashkenazi Jewish descent.
Genetics in medicine : official journal of the American College of Medical Genetics - 1 Sept 2023
Roberts Eleanor, van Veen Elke M, Byers Helen, Barnett-Griness Ofra, Gronich Naomi, Lejbkowicz Flavio, Pinchev Mila, Smith Miriam J, Howell Anthony, Newman William G, Woodward Emma R, Harkness Elaine F, Brentnall Adam R, Cuzick Jack, Rennert Gad, Howell Sacha J, Evans D Gareth
Abstract excerpt
PURPOSE: Polygenic risk scores (PRSs) are a major component of accurate breast cancer (BC) risk prediction but require ethnicity-specific calibration. Ashkenazi Jewish (AJ) population is assumed to be of White European (WE) origin in some commercially available PRSs despite differing effect allele frequencies (EAFs). We conducted a case-control study of WE and AJ women from the Predicting Risk of Cancer at...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.