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Article

The importance of ethnicity: Are breast cancer polygenic risk scores ready for women who are not of White European origin?

International journal of cancer - 1 Jan 2022

Evans D Gareth, van Veen Elke M, Byers Helen, Roberts Eleanor, Howell Anthony, Howell Sacha J, Harkness Elaine F, Brentnall Adam, Cuzick Jack, Newman William G

Abstract excerpt

Polygenic risk scores (PRS) for disease risk stratification show great promise for application in general populations, but most are based on data from individuals of White European origin. We assessed two well validated PRS (SNP18, SNP143) in the Predicting-Risk-of-Cancer-At-Screening (PROCAS) study in North-West England for breast cancer prediction based on ethnicity. Overall, 9475 women without breast cancer at...

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Identifiers

PMID: 34460111
DOI: 10.1002/ijc.33782
PMCID: PMC9290473

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