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Article

Genome-wide transcriptional analysis of BRD4-regulated genes and pathways in human glioma U251 cells

16 Mar 2018

Abstract excerpt

Bromodomain containing 4 (BRD4), a member of the bromodomain and extra-terminal family, has become a promising drug target for numerous types of cancer. BRD4 has been reported to be deregulated in gliomas; however, the precise molecular pathways regulated by BRD4 remained elusive. In the present study, BRD4 expression was silenced in the glioma cell line U251 and the results demonstrated that BRD4 knockdown...

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PMID: 29568956
DOI: 10.3892/ijo.2018.4324

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