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Article

Molecular Basis of Unequal Alternative Splicing of Human SCD5 and Its Alteration by Natural Genetic Variations.

International journal of molecular sciences - 30 Mar 2023

Orosz Gabriella, Szabó Luca, Bereti Szanna, Zámbó Veronika, Csala Miklós, Kereszturi Éva

Abstract excerpt

Alternative splicing (AS) is a major means of post-transcriptional control of gene expression, and provides a dynamic versatility of protein isoforms. Cancer-related AS disorders have diagnostic, prognostic and therapeutic values. Changes in the expression and AS of human stearoyl-CoA desaturase-5 (SCD5) are promising specific tumor markers, although the transcript variants (TVs) of the gene have not yet been...

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PMID: 37047490
DOI: 10.3390/ijms24076517
PMCID: PMC10095032

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