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Article

Analysis of splice variants of the human protein disulfide isomerase (P4HB) gene.

BMC genomics - 4 Nov 2020

Kajihara Daniela, Hon Chung-Chau, Abdullah Aimi Naim, Wosniak João, Moretti Ana Iochabel S, Poloni Joice F, Bonatto Diego, Hashimoto Kosuke, Carninci Piero, Laurindo Francisco R M

Abstract excerpt

BACKGROUND: Protein Disulfide Isomerases are thiol oxidoreductase chaperones from thioredoxin superfamily with crucial roles in endoplasmic reticulum proteostasis, implicated in many diseases. The family prototype PDIA1 is also involved in vascular redox cell signaling. PDIA1 is coded by the P4HB gene. While forced changes in P4HB gene expression promote physiological effects, little is known about endogenous...

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PMID: 33148170
DOI: 10.1186/s12864-020-07164-y
PMCID: PMC7640458

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