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Article

Initiation on the divergent Type I cadicivirus IRES: factor requirements and interactions with the translation apparatus.

Nucleic acids research - 20 Apr 2016

Asnani Mukta, Pestova Tatyana V, Hellen Christopher U T

Abstract excerpt

Cadicivirus (CDV) is unique amongst picornaviruses in having a dicistronic genome with internal ribosomal entry sites (IRESs) preceding both open reading frames. Here, we investigated initiation on the 5'-terminal IRES. We report that the 982-nt long 5'UTR comprises 12 domains (d1-d12), five of which (d8-d12, nts 341-950) constitute a divergent Type I IRES. It comprises central elements (the apex of d10, d11 and...

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Source

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Identifiers

PMID: 26873921
DOI: 10.1093/nar/gkw074
PMCID: PMC4838371

Genes

PCBP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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