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Article

ADAR1 Biology Can Hinder Effective Antiviral RNA Interference.

Journal of virology - 27 Apr 2023

Uhl Skyler, Jang Chanyong, Frere Justin J, Jordan Tristan X, Simon Anne E, tenOever Benjamin R

Abstract excerpt

Viruses constantly evolve and adapt to the antiviral defenses of their hosts. The biology of viral circumvention of these selective pressures can often be attributed to the acquisition of novel antagonistic gene products or by rapid genome change that prevents host recognition. To study viral evasion of RNA interference (RNAi)-based defenses, we established a robust antiviral system in mammalian cells using...

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Identifiers

PMID: 37017521
DOI: 10.1128/jvi.00245-23
PMCID: PMC10134826

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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