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Regulated cell death pathways: New twists in modulation of BCL2 family function

1 Jun 2009

Abstract excerpt

A number of cell death pathways have been recognized. Though apoptosis and autophagy have been well characterized, programmed necrosis has recently received attention and may provide clinical alternatives to suppress resistant tumors. Necrosis is primarily characterized by large-scale permeabilization, swelling, and rupture of cell membranes and the release of pro-inflammatory cytokines. Traditionally, necrosis...

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PMID: 19509269
DOI: 10.1158/1535-7163.mct-08-0895

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