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Article

The in vivo evidence for regulated necrosis

30 Apr 2017

Abstract excerpt

Necrosis is a hallmark of several widespread diseases or their direct complications. In the past decade, we learned that necrosis can be a regulated process that is potentially druggable. RIPK3- and MLKL-mediated necroptosis represents by far the best studied pathway of regulated necrosis. During necroptosis, the release of damage-associated molecular patterns (DAMPs) drives a phenomenon referred to as...

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PMID: 28462528
DOI: 10.1111/imr.12551

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