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Article

Analysis of the expression profile of Dickkopf-1 gene in human glioma and the association with tumor malignancy

28 Oct 2010

Abstract excerpt

BACKGROUND: Gliomas represent the most common primary malignant brain tumors, yet little is known about the molecular pathogenesis of these tumors. The highly-regulated Wnt signal transduction pathway is essential for normal developmental processes, and defects in the pathway are closely linked to oncogenesis. Dickkopf-1 (DKK-1) is a secreted protein that acts as a potent inhibitor of the Wnt pathway. The aim of...

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PMID: 21029453
DOI: 10.1186/1756-9966-29-138

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