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Article

MTHFD1L confers a poor prognosis and malignant phenotype in esophageal squamous cell carcinoma by activating the ERK5 signaling pathway.

Experimental cell research - 1 Jun 2023

Zhou Jianfeng, Yang Yushang, Cheng Jiahan, Luan Siyuan, Xiao Xin, Li Xiaokun, Fang Pinhao, Gu Yimin, Shang Qixin, Zhang Hanlu, Chen Longqi, Zeng Xiaoxi, Yuan Yong

Abstract excerpt

MTHFD1L, a key enzyme of folate metabolism, is seldom reported in cancer. In this study, we investigate the role of MTHFD1L in the tumorigenicity of esophageal squamous cell carcinoma (ESCC). ESCC tissue microarrays (TMAs) containing 177 samples from 109 patients were utilized to evaluate whether MTHFD1L expression, determined using immunohistochemical analysis, is a prognostic indicator for ESCC patients. The...

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PMID: 37004948
DOI: 10.1016/j.yexcr.2023.113584

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