Prognostic impact of MutT homolog‐1 expression on esophageal squamous cell carcinoma

doi:10.1002/cam4.979

Article

Prognostic impact of MutT homolog‐1 expression on esophageal squamous cell carcinoma

5 Dec 2016

Abstract excerpt

MutT homolog-1 (MTH1) is a pyrophosphatase that acts on oxidized nucleotides and hydrolyzes 8-oxo-2'-deoxyguanosine triphosphate in deoxynucleoside triphosphate pool to prevent its incorporation into nuclear and mitochondrial DNA, result in reduce cytotoxicity in tumor cells. MTH1 is overexpressed in various cancers and is considered as a therapeutic target. Environmental factors such as cigarette smoking and...

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