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Article

Dietary Supplementation with Milk Lipids Leads to Suppression of Developmental and Behavioral Phenotypes of Hyperexcitable Drosophila Mutants.

Neuroscience - 1 Jun 2023

Kasuya Junko, Johnson Wayne, Chen Hung-Lin, Kitamoto Toshihiro

Abstract excerpt

Dietary modifications often have a profound impact on the penetrance and expressivity of neurological phenotypes that are caused by genetic defects. Our previous studies in Drosophila melanogaster revealed that seizure-like phenotypes of gain-of-function voltage-gated sodium (Nav) channel mutants (paraShu, parabss1, and paraGEFS+), as well as other seizure-prone "bang-sensitive" mutants (eas and sda), were...

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Identifiers

PMID: 37004908
DOI: 10.1016/j.neuroscience.2023.03.027
PMCID: PMC10200772

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