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Article

Actionable Genetic Screens Unveil Targeting of AURKA, MEK, and Fatty Acid Metabolism as an Alternative Therapeutic Approach for Advanced Melanoma.

The Journal of investigative dermatology - 1 Oct 2023

Marocchi Federica, Palluzzi Fernando, Nicoli Paola, Melixetian Marine, Lovati Giulia, Bertalot Giovanni, Pece Salvatore, Ferrucci Pier Francesco, Bossi Daniela, Lanfrancone Luisa

Abstract excerpt

Despite the remarkable improvements achieved in the management of metastatic melanoma, there are still unmet clinical needs. A considerable fraction of patients does not respond to immune and/or targeted therapies owing to primary and acquired resistance, high-grade immune-related adverse events, and a lack of alternative treatment options. To design effective combination therapies, we set up a functional ex vivo...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mitogen-Activated Protein Kinase Kinases

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Share to Proto-Oncogene Proteins B-raf

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Source

Identifiers

PMID: 37003468
DOI: 10.1016/j.jid.2023.03.1665

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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