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Metabolic Lipids in Melanoma Enable Rapid Determination of Actionable BRAF-V600E Mutation with Picosecond Infrared Laser Mass Spectrometry in 10 s.

Analytical chemistry - 26 Sept 2023

Katz Lauren, Kiyota Taira, Woolman Michael, Wu Megan, Pires Layla, Fiorante Alexa, Ye Lan Anna, Leong Wey, Berman Hal K, Ghazarian Danny, Ginsberg Howard J, Das Sunit, Aman Ahmed, Zarrine-Afsar Arash

Abstract excerpt

Rapid molecular profiling of biological tissues with picosecond infrared laser mass spectrometry (PIRL-MS) has enabled the detection of clinically important histologic types and molecular subtypes of human cancers in as little as 10 s of data collection and analysis time. Utilizing an engineered cell line model of actionable BRAF-V600E mutation, we observed statistically significant differences in 10 s PIRL-MS...

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PMID: 37695851
DOI: 10.1021/acs.analchem.3c02901

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