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SEMA6C: a novel adhesion-independent FAK and YAP activator, required for cancer cell viability and growth

31 Mar 2023

Abstract excerpt

Transmembrane semaphorins are signaling molecules, controlling axonal wiring and embryo development, which are increasingly implicated in human diseases. Semaphorin 6C (Sema6C) is a poorly understood family member and its functional role is still unclear. Upon targeting Sema6C expression in a range of cancer cells, we observed dramatic growth suppression, decreased ERK phosphorylation, upregulation of cell cycle...

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PMID: 37002363
DOI: 10.1007/s00018-023-04756-1

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