Article
The Mineralocorticoid Receptor—How to Get Away with Promiscuity
1 Jul 2006
Abstract excerpt
Isidore Edelman (1) had difficulty publishing his groundbreaking paper on isolation and characterization of the mineralocorticoid receptor (2), because reviewers argued—not without good reasons—that he might have gotten the wrong receptor. They objected that its affinity was admittedly greatest for aldosterone, but considering the fact that the intracellular concentration of glucocorticoids was higher by a factor...
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