Article
11 beta-Hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess.
Endocrine reviews - 1 Feb 1997
White P C, Mune T, Agarwal A K
Abstract excerpt
Whereas aldosterone is normally a much stronger mineralocorticoid than cortisol in vivo, mineralocorticoid receptors have identical in vitro affinities for these hormones. The in vivo specificity of the receptors is, at least in part, the result of activity of 11-HSD, an enzyme located in most mi...
Topics
- 11-beta-Hydroxysteroid Dehydrogenases
- ACTH Syndrome, Ectopic
- Aldosterone
- Glycyrrhiza
- Humans
- Hydroxysteroid Dehydrogenases
- Hypertension
- Isoenzymes
- Mineralocorticoids
- Mutation
- Plants, Medicinal
- Receptors, Mineralocorticoid
- Syndrome