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Primitive haematopoiesis in the human placenta gives rise to macrophages with epigenetically silenced HLA-DR

30 Mar 2023

Abstract excerpt

The earliest macrophages are generated during embryonic development from erythro-myeloid progenitors (EMPs) via primitive haematopoiesis. Although this process is thought to be spatially restricted to the yolk sac in the mouse, in humans, it remains poorly understood. Human foetal placental macrophages, or Hofbauer cells (HBC), arise during the primitive haematopoietic wave ~18 days post conception and lack...

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PMID: 36997537
DOI: 10.1038/s41467-023-37383-2

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